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R&D Scientist - Advanced in Santa Clara, CA at Volt

Date Posted: 3/14/2019

Job Snapshot

Job Description

Research Associate Oligonucleotide Synthesis Chemist

Santa Clara, CA

Job Description:

We are seeking a research associate to work with a team developing and scaling novel chemistries for RNA synthesis. Key responsibilities will be the production and purification of synthetic RNA and chemically modified synthetic RNA using automated solid-phase synthesis techniques. Other responsibilities will include sample preparation, data acquisition, and data analysis of synthetic oligonucleotides by LC-MS using Agilent QTOF instruments and software. Detailed record keeping of all steps in the workflow is imperative. You will be pushing RNA synthesis state of the art using proprietary TC-RNA chemistry, and will be responsible for ordering, maintaining, and monitoring an inventory of chemical reagents, as well as maintenance and monitoring of the hardware components used for the synthesis, purification and analysis of the RNA products.

Works on problems of moderate scope in which analysis of situation or data requires a review of identifiable factors. 

Exercises judgment within defined procedures and practices to determine appropriate action.

Required Qualifications:

- MS/MA in Chemistry or Biochemistry, or equivalent.

- 2+ years' experience synthetic organic and/or analytical chemistry.

- Experience with HPLC purification techniques

- Experience with Mass Spectrometry.

- Practiced in the development and bottling of buffers and reagents, as well as the management of laboratory chemicals and raw materials inventories.

- Ability to work independently and to execute and troubleshoot new methods.

- Excellent time management, record keeping, teamwork and communication skills.

- Computer literacy including proficiency with Word and Excel

Desired Qualifications

- Experience in solid-phase oligonucleotide synthesis, using and trouble-shooting automated solid-phase synthesizers and optimizing synthetic protocols and reaction schemas.

- Experience in the optimization of purification protocols for oligonucleotides (RNA and DNA) via HPLC.

- Experience with Mass Hunter software for data acquisition and analysis

- Hands-on experience manipulating and synthesizing RNA in an R&D environment and practiced in anhydrous and RNAse-free lab techniques.

Volt is an Equal Opportunity Employer